PSVIII-21 Modulation of Goat Plasma Proteins Using Different Preparations of Garlic

Abstract The main objective of this study was to evaluate the effect different garlic preparations on plasma protein concentration and Galectin secretion in goat blood. Inflammatory diseases caused by pathogens including gastrointestinal parasites impact gut health productivity. Changes are indicators status with application inflammatory disease diagnosis prognosis. Galectins (Gals) small soluble proteins that contain one or two carbohydrate recognition domains (CRDS). ‘Prototype’ galectin-1, -2, -7, CRD, 3 is chimeric, galectin-4, -8, -9 -12, tandem repeat galectins CRDs. regulate biologic functions, immunity pathogenesis can serve as biomarkers. Garlic (Allium sativum) a medicinal herb has anti-parasitic immuno-modulatory effects. Six (N=6) adult female clinically healthy Boer x Spanish goats were used. Blood collected from jugular vein treated concentrations fresh garlic, allicin, barrier, aged (Sigma aldich). Total evaluated using BCA assay. Secretion Gals 1(Prototype), Gal (chimera type) 9 (tandem-repeat determined commercial ELISA kits recommended manufacturer. All variables assessed SAS analysis software (version 9.0, Sas Institute Cary, p≤0.05). treatment had dose dependent total secretion. affected types garlic. Allicin (72.86μg/ml) reduced proteins. No change observed (156.334μg/ml) barrier (160.73μg/ml). increased (6.3%) detected (Gals 1 >9 >3), variable response preparation (Garlic > secretion). modulates Studies needed determine leukocytes molecular targets